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CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen (Leu6, HTA1)
Function:
- antigen-presenting protein that binds self & non-self lipid & glycolipid antigens & presents them to T-cell receptors on natural killer T-cells
- heterodimer with B2M (beta-2-microglobulin)
- interacts with CD74
Structure: contains 1 Ig-like domain (immunoglobulin-like)
Compartment:
- cell membrane
- endosome membrane
- subject to intracellular trafficking between the cell membrane & endosomes
- localizes to cell surface lipid rafts
Expression:
- expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, & in various other tissues
- normal B cells stain negative with antibody
Pathology:
- expressed in:
a) dendritic cells in dermis/epidermis of benign inflammatory skin disorders
b) Langerhans cell histiocytosis
c) myeloid leukemias
d) some B cell malignancies
e) dendritic cells in most peripheral cutaneous T cell lymphomas
- most B cell malignancies stain negative with antibody
Related
CD1a Ag in tissue
General
CD1
Properties
SIZE: entity length = 327 aa
MW = 37 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-16}
N-glycosylation site {N37}
N-glycosylation site {N60}
N-glycosylation site {N74}
Glycolipid binding {90-94}
cysteine residue {C119}
MODIFICATION: cysteine residue {C183}
N-glycosylation site {N145}
binding site
SITE: 171-171
FOR-BINDING-OF: Glycolipid
cysteine residue {C183}
MODIFICATION: cysteine residue {C119}
immunoglobulin superfamily domain {184-291}
MOTIF: cysteine residue {C223}
MODIFICATION: cysteine residue {C278}
cysteine residue {C278}
MODIFICATION: cysteine residue {C223}
transmembrane domain {301-321}
Database Correlations
OMIM 188370
UniProt P06126
PFAM correlations
Entrez Gene 909
Kegg hsa:909
References
- OMIM :accession 188370
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 909