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CD19; B-lymphocyte antigen CD19; differentiation antigen CD19; B-lymphocyte surface antigen B4; Leu-12

Function: - assembles with the antigen receptor of B lymphocytes to decrease the threshold for antigen receptor-dependent stimulation - forms a complex with CD21, CD81 & CD225 in the membrane of mature B cells - interacts with VAV - interacts with GRB2 & SOS when phosphorylated on Tyr-348 &/or Tyr-378 - interacts with PLCG2 when phosphorylated on Tyr-409 - phosphorylated on Ser & Thr upon DNA damage, probably by ATM or ATR - phosphorylated on Tyr following B-cell activation - CD19 physically associates with lyn [2] - signal transduction occurs through the CD19/lyn complex Structure: - contains 2 Ig-like C2-type domain (immunoglobulin-like) Compartment: membrane Expression: - earliest B cell antigen in fetal tissue - pre-B cells - B-cells - follicular dendritic cells - absent in plasma cells Pathology: - defects in CD19 are a cause of hypogammaglobulinemia

Related

B lymphocyte CD19 Ag in tissue CD19 cells in specimen Lyn proto-oncogene protein (tyrosine-protein kinase Lyn, LYN)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein phosphoprotein

Properties

SIZE: entity length = 556 aa MW = 61 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} immunoglobulin superfamily domain {20-113} MOTIF: cysteine residue {C38} MODIFICATION: cysteine residue {C97} N-glycosylation site {N86} cysteine residue {C97} MODIFICATION: cysteine residue {C38} N-glycosylation site {N125} N-glycosylation site {N138} immunoglobulin superfamily domain {176-277} MOTIF: N-glycosylation site {N181} cysteine residue {C200} MODIFICATION: cysteine residue {C261} Ser phosphorylation site {S227} cysteine residue {C261} MODIFICATION: cysteine residue {C200} N-glycosylation site {N265} transmembrane domain {292-313} Tyr phosphorylation site {Y348} Tyr phosphorylation site {Y378} Tyr phosphorylation site {Y409} Tyr phosphorylation site {Y439} Ser phosphorylation site {S497}

Database Correlations

OMIM 107265 UniProt P15391 Entrez Gene 930 Kegg hsa:930

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
  2. Myers DE, Jun X, Waddick KG, Forsyth C, Chelstrom LM, Gunther RL, Tumer NE, Bolen J, Uckun FM. Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9575-9. Erratum in: Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1357. PMID: 7568175
  3. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  4. Entrez Gene :accession 930
  5. CD19base; Note: CD19 mutation db http://bioinf.uta.fi/CD19base/
  6. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD19
  7. UniProt :accession P15391