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epithelial discoidin domain-containing receptor 1; epithelial discoidin domain receptor 1; tyrosine kinase DDR; discoidin receptor tyrosine kinase; tyrosine-protein kinase CAK; cell adhesion kinase; TRK E; protein-tyrosine kinase RTK 6; HGK2; CD167 antigen-like family member A; CD167a (DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE)
Function:
- may be involved in cell-cell interactions & recognition
Structure:
- Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 1 F5/8 type C domain
- contains 1 protein kinase domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed at low levels in most adult tissues
- highest expression in the brain & lung
Pathology:
- abundant in breast carcinoma cell lines
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 913 aa
MW = 101 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-18}
coagulation factors 5/8 type C domain (FA58C) {31-185}
MOTIF: cysteine residue {C31}
MODIFICATION: cysteine residue {C185}
cysteine residue {C185}
MODIFICATION: cysteine residue {C31}
N-glycosylation site {N211}
N-glycosylation site {N260}
N-glycosylation site {N371}
proline-rich region
SITE: 377-415
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N394}
transmembrane domain {417-443}
proline-rich region
SITE: 476-601
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y513}
kinase domain
SITE: 610-905
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 616-624
ATP-binding site
NAME: ATP-binding site
SITE: 655-655
aspartate residue {D766}
Tyr phosphorylation site {Y792}
Tyr phosphorylation site {Y796}
Tyr phosphorylation site {Y797}
Database Correlations
OMIM 600408
UniProt Q08345
PFAM correlations
Kegg hsa:780
ENZYME 2.7.10.1
References
UniProt :accession Q08345