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CD15, Lewis X or X-hapten
Function:
- Lewis X, component of ligand for CD62P/P-selectin
Gal-B(1,4)-GlcNAc-B(1,3)-Gal
| |
a(1,3)-Fuc B(1,4)-GlcNAc
(------ Lewis X ------)
Laboratory: detected by Leu-M1 antibody.
Expression:
- myeloid cells ~90%
- activated B and T cells
- eosinophils
- erythroid cells & platelets stain negatively with antibody
Pathology:
- expressed in:
a) Reed-Sternberg cells
b) 20% of T cell lymphomas
c) 5% of B cell lymphomas
d) 50% carcinomas
Related
CD15 Ag in tissue
CD15 cells in specimen
CD62P, P-selectin; granule membrane protein 140; GMP-140; PADGEM; leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62 antigen-like family member P (SELP, GMRP, GRMP)
neutrophil or polymorphonuclear leukocyte (PMN, poly)
Specific
CD15s or sialyl Lewis X
CD15u or sulfated CD15
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
Properties
COMPARTMENT: plasma membrane
CELL: monocyte
neutrophil
MOTIF: glycosylation site
membrane region
Database Correlations
OMIM 104230
References
- Springer & Lasky News & Views Nature 349:196 1991
- Feizi TIBS 16:84 1991
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002