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CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein

Function: - monocyte differentiation antigen - interacts with apoptotic cells triggering phagocytosis of monocytes/macrophages [2] - cooperates with MD-2 & TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) - acts via MyD88, TIRAP & TRAF6, leading to NF-kappa-B activation, cytokine secretion & the inflammatory response - up-regulates cell surface molecules, including adhesion molecules - component of lipopolysaccharide receptor Structure: - contains 11 LRR repeats (leucine-rich repeats) Compartment: cell membrane; lipid-anchor, GPI-anchor Expression: - expressed strongly on the surface of monocytes - macrophages ~90% - Langerhans cells - dendritic cells - B cells - granulocytes - weak, ~30% - myeloid progenitors stain negatively with antibody Pathology: - expressed in: a) B cell CLL b) follicular center cell lymphoma ~80% c) diffuse large B cell lymphoma ~40% d) AML-M4/M5 ~50-90% e) AML-M0/, AML-M1, AML-M2, AML-M3, AML-M6, AML-M7 stain negatively with antibody

Related

CD14 Ag in tissue CD14 cells in specimen

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glypiated protein

Properties

SIZE: entity length = 375 aa MW = 40 kD COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: epithelial cell MOTIF: signal sequence {1-19} cysteine residue {C25} MODIFICATION: cysteine residue {C36} cysteine residue {C34} MODIFICATION: cysteine residue {C51} cysteine residue {C36} MODIFICATION: cysteine residue {C25} N-glycosylation site {N37} cysteine residue {C51} MODIFICATION: cysteine residue {C34} leucine-rich repeat SITE: 54-82 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 83-118 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 119-144 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 145-172 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N151} leucine-rich repeat SITE: 173-196 MOTIF: leucine residue (SEVERAL) cysteine residue {C187} MODIFICATION: cysteine residue {C217} leucine-rich repeat SITE: 197-224 MOTIF: leucine residue (SEVERAL) cysteine residue {C217} MODIFICATION: cysteine residue {C187} leucine-rich repeat SITE: 225-251 MOTIF: leucine residue (SEVERAL) cysteine residue {C241} MODIFICATION: cysteine residue {C272} leucine-rich repeat SITE: 252-278 MOTIF: leucine residue (SEVERAL) cysteine residue {C272} MODIFICATION: cysteine residue {C241} leucine-rich repeat SITE: 279-299 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N282} leucine-rich repeat SITE: 300-321 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 322-349 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N323} glycosyl phosphatidylinositol [GPI] membrane anchor {N345}

Database Correlations

OMIM 158120 UniProt P08571 Pfam PF00560 Entrez Gene 929 Kegg hsa:929

References

  1. Wright et al Science 249:1431 1990
  2. Devitt et al. Nature 392:505-9, 1998
  3. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  4. Entrez Gene :accession 929
  5. Wikipedia; Note: CD14 entry http://en.wikipedia.org/wiki/CD14

Component-of

lipopolysaccharide (LPS) receptor