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CD11c; integrin alpha-X; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; Leu M5; CD11 antigen-like family member C (ITGAX, CD11C)
Function:
- component of integrin alpha-X/beta-2 (CD11c/CD18)
Structure:
- integrin I-domain (insert) is a VWFA domain
- integrins with I-domains do not undergo protease cleavage
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
- contains 1 VWFA domain
Compartment: membrane
Expression:
- activated CD4/CD8+ T cells ~50%
- granulocytes
- lymphocytes
- macrophages
- activated microglia
- NK cells
- predominantly expressed in monocytes & granulocytes
Pathology:
- expressed in:
a) AML-M4/M5 ~50%
b) hairy cell leukemia (virtually all)
c) B-CLL (associated with good prognosis)
- genetic variations in CD11c influence susceptibility to systemic lupus erythematosus [3]
Related
CD11c Ag in tissue
General
CD11
Properties
SIZE: entity length = 1163 aa
MW = 128 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
FG-GAP {34-87}
MOTIF: N-glycosylation site {N61}
cysteine residue {C69}
MODIFICATION: cysteine residue {C76}
cysteine residue {C76}
MODIFICATION: cysteine residue {C69}
consensus repeat {88}
SEQUENCE-IS: FG-GAP
N-glycosylation site {N89}
cysteine residue {C108}
MODIFICATION: cysteine residue {C126}
cysteine residue {C126}
MODIFICATION: cysteine residue {C108}
VWFA domain {165-351}
N-glycosylation site {N392}
consensus repeat {401}
SEQUENCE-IS: FG-GAP
FG-GAP {402-453}
FG-GAP {455-517}
MOTIF: Ca+2-binding site
SITE: 466-474
FG-GAP {518-576}
MOTIF: Ca+2-binding site
SITE: 530-538
FG-GAP {581-633}
MOTIF: Ca+2-binding site
SITE: 593-601
cysteine residue {C655}
MODIFICATION: cysteine residue {C712}
N-glycosylation site {N697}
cysteine residue {C712}
MODIFICATION: cysteine residue {C655}
N-glycosylation site {N735}
cysteine residue {C771}
MODIFICATION: cysteine residue {C777}
cysteine residue {C777}
MODIFICATION: cysteine residue {C771}
cysteine residue {C848}
MODIFICATION: cysteine residue {C863}
cysteine residue {C863}
MODIFICATION: cysteine residue {C848}
N-glycosylation site {N899}
N-glycosylation site {N939}
cysteine residue {C998}
MODIFICATION: cysteine residue {C1022}
cysteine residue {C1022}
MODIFICATION: cysteine residue {C998}
cysteine residue {C1027}
MODIFICATION: cysteine residue {C1032}
cysteine residue {C1032}
MODIFICATION: cysteine residue {C1027}
N-glycosylation site {N1050}
transmembrane domain {1108-1128}
GFFKR {1131-1135}
Database Correlations
OMIM 151510
UniProt P20702
PFAM correlations
Entrez Gene 3687
Kegg hsa:3687
References
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 3687
- Hom G, Graham RR, Modrek B et al
Association of systemic lupus erythematosus with C8orf13-BLK
and ITGAM-ITGAX.
N Engl J Med. 2008 Feb 28;358(9):900-9
PMID: 18204098
Component-of
integrin alpha-X/beta-2 (CD11c/CD18)