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CD112; poliovirus receptor-related protein 2; Herpes virus entry mediator B; nectin 2 (PVRL2, HVEB, PRR2)
Function:
- cell adhesion
- component of the adherens junction
- can form trans-heterodimers with PVRL3/nectin-3
- interacts with CD226
- binds with low affinity to TIGIT
Structure:
- belongs to the nectin family
- contains 2 Ig-like C2-type domains
- contains 1 Ig-like V-type domain
Compartment:
- cell membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2; alpha, delta
Expression: ubiquitous
Pathology:
- interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) & pseudorabies virus (PRV) envelope glycoprotein
- functions as an entry receptor for these viruses
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
phosphoprotein
Properties
SIZE: entity length = 538 aa
MW = 58 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-31}
immunoglobulin superfamily domain {32-156}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C140}
N-glycosylation site {N137}
cysteine residue {C140}
MODIFICATION: cysteine residue {C54}
immunoglobulin superfamily domain {162-256}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C238}
cysteine residue {C238}
MODIFICATION: cysteine residue {C183}
immunoglobulin superfamily domain {261-345}
MOTIF: cysteine residue {C283}
MODIFICATION: cysteine residue {C329}
N-glycosylation site {N324}
cysteine residue {C329}
MODIFICATION: cysteine residue {C283}
transmembrane domain {361-381}
Ser phosphorylation site {S433}
Ser phosphorylation site {S520}
Database Correlations
OMIM 600798
UniProt Q92692
PFAM correlations
Entrez Gene 5819
Kegg hsa:5819
References
- http://www.pathologyoutlines.com/cd100247.html
21 June 2005
- UniProt Q92692