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CD111; poliovirus receptor-related protein 1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Herpesvirus Ig-like receptor; HIgR; nectin-1 (PVRL1, HVEC, PRR1)
Function:
- cell adhesion
- promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers
- heterophilic interactions have been detected between PVRL1/nectin-1 & PVRL3/nectin-3 & between PVRL1/nectin-1 & PVRL4/nectin-4
- can form trans-heterodimers with PVRL3/nectin-3 & with PVRL4/nectin-4
- interacts (via C-terminus) with afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions
- interacts with integrin alphaV/beta3
- component of the adherens junction
Structure:
- belongs to the nectin family
- contains 2 Ig-like C2-type domains
- contains 1 Ig-like V-type domain
Compartment:
- isoforms alpha & delta:
- cell membrane; single-pass type 1 membrane protein
- isoform gamma: secreted
Alternative splicing: named isoforms=3; alpha, gamma, delta
Expression:
- widely expressed
- myeloid, monocyte, megakaryocytes & erythroid lineage
- epithelial cells
- neurons
- endothelium
Pathology:
- receptor for herpes simplex viruses 1 & 2 & pseudorabies virus
- functions as an entry receptor for these viruses
- mutations associated with:
- ectodermal dysplasia type 4 (ED4) or Margarita island type of ectodermal dysplasia with cleft lip/palate
- cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or Zlotogora-Ogur syndrome
General
adhesion receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
immunoglobulin superfamily protein
Properties
SIZE: entity length = 517 aa
MW = 57 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-30}
immunoglobulin superfamily domain {31-141}
MOTIF: N-glycosylation site {N36}
cysteine residue {C51}
MODIFICATION: cysteine residue {C124}
N-glycosylation site {N72}
cysteine residue {C124}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N139}
immunoglobulin superfamily domain {149-238}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C226}
N-glycosylation site {N202}
cysteine residue {C226}
MODIFICATION: cysteine residue {C172}
immunoglobulin superfamily domain {247-334}
MOTIF: cysteine residue {C269}
MODIFICATION: cysteine residue {C316}
N-glycosylation site {N286}
N-glycosylation site {N297}
N-glycosylation site {N307}
cysteine residue {C316}
MODIFICATION: cysteine residue {C269}
N-glycosylation site {N332}
transmembrane domain {356-376}
Ser phosphorylation site {S422}
Ser phosphorylation site {S434}
Ser phosphorylation site {S435}
glutamate-rich region {437-444}
MOTIF: glutamate residue (SEVERAL)
glycine-rich region {445-449}
Tyr phosphorylation site {Y468}
Database Correlations
OMIM correlations
MORBIDMAP 600644
UniProt Q15223
PFAM correlations
Entrez Gene 5818
Kegg hsa:5818
References
- http://www.pathologyoutlines.com/cd100247.html
21 June 2005
- UniProt Q15223