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CD1

Compartment: - during protein synthesis & maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized & pass through endosomes, before trafficking back to the cell surface Expression: - cortical thymocytes ~70% - activated T cells - Langerhans cells - interdigitating dendritic cells - pre-T ALL with cortical thymocyte phenotype - Langerhans cell histiocytosis. - mature peripheral T cells stain negatively with antibody.

Related

CD1 Ag in tissue CD1 blasts in blood CD1 blasts in bone marrow CD1 blasts in specimen CD1 cells in blood

Specific

CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen (Leu6, HTA1) CD1C; T-cell surface glycoprotein CD1c CD1D; T-cell surface glycoprotein CD1d; R3G1 (CD1D) CD1E; T-cell surface glycoprotein CD1e; R2G1 (CD1E) T-cell surface glycoprotein CD1b; CD1b (CD1B)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein immunoglobulin superfamily protein

Properties

COMPARTMENT: plasma membrane CELL: T-cell WITHIN: thymus MOTIF: glycosylation site membrane region

Database Correlations

OMIM 188370

References

  1. OMIM :accession 188370
  2. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002