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C-C chemokine receptor type 9; C-C CKR-9; CC-CKR-9; CCR-9; GPR-9-6; G-protein coupled receptor 28; CDw199 (CCR9, CMKBR9, GPR28)
Function:
- receptor for chemokine SCYA25/TECK
- subsequently transduces a signal by increasing the intracellular Ca+2
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- highly expressed in the thymus & low in lymph nodes & spleen
Pathology:
- alternative coreceptor with CD4 for HIV-1 infection
Miscellaneous:
- EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 369 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-53}
MOTIF: N-glycosylation site {N32}
transmembrane domain {54-74}
cytoplasmic loop {75-85}
transmembrane domain {86-106}
exoplasmic loop {107-127}
MOTIF: cysteine residue {C119}
MODIFICATION: cysteine residue {C198}
transmembrane domain {128-148}
cytoplasmic loop {149-166}
transmembrane domain {167-187}
exoplasmic loop {188-218}
MOTIF: cysteine residue {C198}
MODIFICATION: cysteine residue {C119}
transmembrane domain {219-239}
cytoplasmic loop {240-254}
transmembrane domain {255-275}
exoplasmic loop {276-300}
transmembrane domain {301-321}
cytoplasmic domain {322-369}
References
- UniProt :accession P51686
- Wikipedia; Note: CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors
Databases & Figures
OMIM 604738
UniProt P51686
Pfam PF00001
Entrez Gene 10803
Kegg hsa:1080
CC ligand and receptor binding