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C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; GPR-CY6; GPRCY6; chemokine receptor-like 1; CKR-L1; TER1; CMKBRL2; CC-chemokine receptor CHEMR1; CDw198 (CCR8, CKRL1, CMKBR8, CMKBRL2)
Function:
- receptor for the chemokine SCYA1/I-309
- may regulate monocyte chemotaxis & thymic cell line apoptosis
- alternative coreceptor with CD4 for HIV-1 infection
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Note: originally thought to be a receptor for SCYA3 & SCYA17 [3]
Interactions
molecular events
General
CC chemokine receptor
Properties
SIZE: entity length = 355 aa
MW = 41 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-35}
transmembrane domain {36-63}
cytoplasmic loop {64-73}
transmembrane domain {74-93}
exoplasmic loop {94-107}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C183}
transmembrane domain {108-129}
cytoplasmic loop {130-146}
transmembrane domain {147-171}
exoplasmic loop {172-202}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C106}
transmembrane domain {203-222}
cytoplasmic loop {223-238}
transmembrane domain {239-263}
exoplasmic loop {264-280}
transmembrane domain {281-304}
cytoplasmic domain {305-355}
References
- UniProt :accession P51685
- Wikipedia; CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors
- Bernardini G et al
Identification of the CC chemokines TARC and macrophage
inflammatory protein-1 beta as novel functional ligands for
the CCR8 receptor.
Eur J Immunol. 1998 Feb;28(2):582-8
PMID: 9521068
Component-of
molecular complex
Databases & Figures
OMIM 601834
UniProt P51685
Pfam PF00001
Entrez Gene 1237
Kegg hsa:1237
CC ligand and receptor binding