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C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; eosinophil eotaxin receptor; CD193 (CCR3, CMKBR3)
Function:
- receptor for a C-C type chemokine
- binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1 delta
- subsequently transduces a signal by increasing the intracellular Ca+2
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in eosinophils
- trace amounts expressed in neutrophils & monocytes
Pathology:
- alternative coreceptor with CD4 for HIV-1 infection
- binds to HIV-1 Tat
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
Properties
SIZE: entity length = 355 aa
MW = 41 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-34}
transmembrane domain {35-62}
cytoplasmic loop {63-72}
transmembrane domain {73-93}
exoplasmic loop {94-107}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C183}
transmembrane domain {108-129}
cytoplasmic loop {130-146}
transmembrane domain {147-171}
exoplasmic loop {172-203}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C106}
transmembrane domain {204-223}
cytoplasmic loop {224-239}
transmembrane domain {240-264}
exoplasmic loop {265-281}
transmembrane domain {282-305}
cytoplasmic domain {306-355}
Database Correlations
OMIM 601268
UniProt P51677
Pfam PF00001
Entrez Gene 1232
Kegg hsa:1232
References
- UniProt :accession P51677
- Wikipedia; CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors