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C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192 (CCR2, CMKBR2)
Function:
- receptor for the MCP-1, MCP-3 & MCP-4 chemokines
- transduces a signal by increasing intracellular Ca+2
Structure:
- N-glycosylated
- belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Pathology:
- alternative coreceptor with CD4 for HIV-1 infection
- binds to HIV-1 Tat
Polymorphism:
- variations in CCR2 are associated with relative resistance to HIV1
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 374 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-42}
MOTIF: N-glycosylation site {N14}
cysteine residue {C32}
MODIFICATION: cysteine residue {C277}
transmembrane domain {43-70}
cytoplasmic loop {71-80}
transmembrane domain {81-100}
exoplasmic loop {101-114}
MOTIF: cysteine residue {C113}
MODIFICATION: cysteine residue {C190}
transmembrane domain {115-136}
cytoplasmic loop {137-153}
transmembrane domain {154-178}
exoplasmic loop {179-206}
MOTIF: cysteine residue {C190}
MODIFICATION: cysteine residue {C113}
transmembrane domain {207-226}
cytoplasmic loop {227-243}
transmembrane domain {244-268}
exoplasmic loop {269-285}
MOTIF: cysteine residue {C277}
MODIFICATION: cysteine residue {C32}
transmembrane domain {286-309}
cytoplasmic domain {310-374}
Database Correlations
OMIM correlations
UniProt P41597
Pfam PF00001
Entrez Gene 1231
KEGG correlations
References
- UniProt :accession P41597
- Wikipedia; CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors
- SeattleSNPs
http://pga.gs.washington.edu/data/ccr2/