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cell cycle progression protein 1 (cell cycle progression restoration protein 8, CCPG1, CCP8, CPR8, KIAA1254)
Function:
- acts as an assembly platform for Rho protein signaling complexes
- limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability & its transforming activity
- does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (putative)
- may be involved in cell cycle regulation
- interacts with MCF2L
- may interact with MCF2, ARHGEF1, BCR, VAV1 & FGD1, but not with TIAM1
- interacts with GTP-bound CDC42 & SRC (putative)
Structure: belongs to the CCPG1 family
Compartment:
- cytoplasmic granule membrane
Alternative splicing: named isoforms=4
General
membrane protein
phosphoprotein
Properties
SIZE: entity length = 757 aa
MW = 87 kD
COMPARTMENT: cellular membrane
MOTIF: MCF2L & SRC interaction {1-308}
MOTIF: Thr phosphorylation site {T99}
Ser phosphorylation site {S101}
Ser phosphorylation site {S104}
arginine-rich region {176-181}
MOTIF: arginine residue (SEVERAL)
transmembrane domain {218-238}
coiled coil {248-272}
coiled coil {306-450}
coiled coil {504-530}
Database Correlations
UniProt Q9ULG6
References
UniProt :accession Q9ULG6