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Cyclin-L2; paneth cell-enhanced expression protein (CCNL2)
Function:
1) transcriptional regulator
2) regulation of pre-mRNA splicing process.
3) modulates expression of critical apoptotic factor
4) interacts with CDC2L1, CDC2L2, SFRS2, SFRS7
5) interacts with the hyperphosphorylated C-terminal domain (CTD) of POLR2A
Structure:
- contains a RS region (Arg-Ser dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors
- this region probably plays a role in protein-protein interactions
- belongs to the cyclin family, cyclin L subfamily
Compartment: nucleus, nucleoplasm; nuclear speckle
Alternative splicing: named isoforms=3
Expression:
- ubiquitously expressed
- higher expression level observed in ovary, heart, liver, pancreas
General
cyclin L
Properties
SIZE: entity length = 520 aa
MW = 58 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Cyclin-like 1 {83-185}
Cyclin-like 2 {198-282}
Ser phosphorylation site {S330}
Ser phosphorylation site {S345}
Ser phosphorylation site {S351}
Ser phosphorylation site {S369}
arginine/serine-rich region (RS domain) {385-423}
MOTIF: serine residue (SEVERAL)
arginine residue (SEVERAL)
Database Correlations
OMIM 613482
UniProt Q96S94
PFAM correlations
Entrez Gene 81669
Kegg hsa:81669
References
UniProt :accession Q96S94