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cyclin E1 (CCNE1)
Function:
- essential for the control of the cell cycle at the G1/S (start) transition
- interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex
- the cyclin subunit imparts substrate specificity to the complex
- interacts with retinoblastoma-binding protein 3 & retinoblastoma-like protein 1
- found in a complex with CDK2, CABLES1 & CCNA1
- part of a complex consisting of UHRF2, CDK2 & CCNE1
- phosphorylation of Thr-395 by GSK3 & of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway phosphorylated upon DNA damage, probably by ATM or ATR
Structure: belongs to the cyclin family, cyclin E subfamily
Compartment: nucleus Alternative
- splicing, named isoforms=2
- lacks 49 residues within the cyclin box & cannot complex with CDK2
Expression:
- highly expressed in testis & placenta
- low levels in bronchial epithelial cells
- G1 cyclin of fibroblasts
- G1/S-specific E1
- expression under transcriptional control [2]
Related
CDK2/cyclin E complex
cell cycle
General
cyclin E
Properties
SIZE: MW = 45-62 kD
COMPARTMENT: cytoplasm
CELL-CYCLE: G1
G1/S
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
Tyr-phosphate
Database Correlations
OMIM 123837
UniProt P24864
PFAM correlations
Entrez Gene 898
Kegg hsa:898
References
- Dulie V, Lees E, Reed SI.
Association of human cyclin E with a periodic G1-S phase
protein kinase.
Science. 1992 Sep 25;257(5078):1958-61.
PMID: 1329201
- Morgan DO.
Principles of CDK regulation.
Nature. 1995 Mar 9;374(6518):131-4. Review.
PMID: 7877684
- UniProt :accession P24864
Component-of
UHRF2/CDK2/CCNE1 complex