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cyclin B1 (CCNB1)
Function:
- essential for the control of the cell cycle at the G2/M (mitosis) transition
- interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF)
- cyclin subunit imparts substrate specificity to the complex
- binds HEI10
- interacts with catalytically active RALBP1 & CDC2 during mitosis to form an endocytotic complex during interphase
- ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. not ubiquitinated during G2/M phases
Structure: belongs to the cyclin family, cyclin AB subfamily
Compartment: cytoplasm. nucleus. centrosome
Expression:
- accumulates steadily during G2 & is abruptly destroyed at mitosis
- G2-specific cyclin B1
- maximum concentrations are reached about mid G2
- tail end of cyclin B1 expression may extend into early M-phase
General
cyclin B
Properties
SIZE: entity length = 433 aa
MW = 48 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: lysine-rich region {51-85}
MOTIF: lysine residue (SEVERAL)
ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
CDK2 interaction {169-177}
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
CDK2 interaction {258-261}
Database Correlations
OMIM 123836
UniProt P14635
PFAM correlations
Entrez Gene 891
Kegg hsa:891
References
- Cordon-Cardo C.
Mutations of cell cycle regulators. Biological and clinical
implications for human neoplasia.
Am J Pathol. 1995 Sep;147(3):545-60. Review.
PMID: 7677168