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cyclin A2 (CCNA2)
Function:
- essential for the control of the cell cycle at the G1/S (start) & the G2/M (mitosis) transitions
- interacts with the CDK2 & CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex
- the cyclin subunit imparts substrate specificity to the complex
- when associated with CDK2 (but not with CDC2), interacts with SCAPER
Structure: belongs to the cyclin family, cyclin AB subfamily
Compartment:
- nucleus, cytoplasm
- cytoplasmic when associated with SCAPER
Expression:
- cyclin A is an S-phase specific cyclin with maximum concentrations expressed in mid S-phase [3]
- expression under transcriptional control [2]
- accumulates steadily during G2 & is abruptly destroyed at mitosis
General
cyclin A
Properties
SIZE: MW = 45-62 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: S
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
References
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147
- Morgan DO.
Principles of CDK regulation.
Nature. 1995 Mar 9;374(6518):131-4. Review.
PMID: 7877684
- Cordon-Cardo C.
Mutations of cell cycle regulators. Biological and clinical
implications for human neoplasia.
Am J Pathol. 1995 Sep;147(3):545-60. Review.
PMID: 7677168
- UniProt :accession P20248
Databases & Figures
OMIM 123835
UniProt P20248
PFAM correlations
Entrez Gene 890
Kegg hsa:890
RB/E2F1 interactions