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cyclin A1 (CCNA1)
Function:
- may be involved in the control of the cell cycle at the G1/S (start) & G2/M (mitosis) transitions
- may primarily function in the control of the germline meiotic cell cycle & additionally in the control of mitotic cell cycle in some somatic cells
- interacts with the CDK2 & the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex
- the cyclin subunit imparts substrate specificity to the complex
- does not bind CDK4 & CDK5 (in vitro)
- the cyclin A1-CDK2 complex interacts with transcription factor E2F-1 & RB proteins
- found in a complex with CDK2, CABLES1 & CCNE1 (putative)
- interacts with KLHDC9
Structure:
- belongs to the cyclin family, cyclin AB subfamily
Expression:
- very high levels in testis & very low levels in brain
- expression increases in early G1 phase & reaches highest levels during the S & G2/M phases
Pathology: found in myeloid Leukemia cell lines
General
cyclin A
Properties
SIZE: entity length = 465 aa
MW = 52 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G1
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
alanine-rich region {388-391}
MOTIF: alanine residue (SEVERAL)
References
UniProt :accession P78396
Databases & Figures
OMIM 604036
UniProt P78396
Entrez Gene 8900
RB/E2F1 interactions