malcavernin (cerebral cavernous malformations 2 protein, CCM2, C7orf22, PP10187)

Function: 1) scaffold protein for MAP2K3-MAP3K3 signaling 2) modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock 3) component of complex with MAP2K3, MAP3K3 & RAC1 4) binds RAC1 directly & independently of its nucleotide-binding Compartment: cytoplasm Pathology: - defects in CCM2 results in cerebral cavernous malformations 2

Properties

SIZE: MW = 49 kD entity length = 444 aa COMPARTMENT: cytoplasm MOTIF: phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 59-248

Database Correlations

OMIM 607929 UniProt Q9BSQ5

References

UniProt :accession Q9BSQ5