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Kynurenine--oxoglutarate transaminase 3 (kynurenine aminotransferase 3, KAT3, cysteine-S-conjugate beta-lyase 2, CCBL2, KAT3, RBMXL1)
Function:
- catalyzes irreversible transamination of the L-tryptophan metabolite L-kinurenine to form kynurenic acid
- may catalyze the beta-elimination of S-conjugates & Se-conjugates of L-selenocysteine, resulting in the cleavage of the C-S or C-Se bond (putative)
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
RS-CH(2)-CH(NH3(+))COO(-) RSH + NH3 + pyruvate
Cofactor: pyridoxal phosphate (putative)
Structure:
- homodimer (putative)
- belongs to the class-1 pyridoxal-phosphate-dependent aminotransferase family
Alternative splicing: named isoforms=2
General
aminotransferase
lyase
Properties
SIZE: MW = 51 kD
entity length = 454 aa
MOTIF: cofactor-binding site [280-280]
FOR-BINDING-OF: pyridoxal phosphate
Database Correlations
UniProt Q6YP21
Pfam PF00155
ENZYME correlations
References
UniProt :accession Q6YP21