E3 SUMO-protein ligase CBX4; chromobox protein homolog 4; polycomb 2 homolog; Pc2; hPc2 (CBX4)

Function: - E3 SUMO-protein ligase - facilitates SUMO1 conjugation by UBE2I - component of polycomb group (PcG) multiprotein PRC1 complex - protein modification; protein sumoylation - phosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity & promotes sumoylation on Lys-494 - interacts with histone H3-K9Me3 (putative) - interacts with SUV39H1 & HIPK2 Structure: contains 1 chromo domain Compartment: nucleus Expression: ubiquitous

General

chromobox protein homolog phosphoprotein

Properties

SIZE: entity length = 560 aa MW = 61 kD COMPARTMENT: cell nucleus MOTIF: chromodomain NAME: chromodomain SITE: 11-69 FOR-BINDING-OF: heterochromatin Ser phosphorylation site {S90} histidine-rich region {378-400} MOTIF: histidine residue (SEVERAL) Ser phosphorylation site {S415} Thr phosphorylation site {T497} alanine-rich region {499-510} MOTIF: alanine residue (SEVERAL)

Database Correlations

OMIM 603079 UniProt O00257 Pfam PF00385 Entrez Gene 8535 Kegg hsa:8535

References

UniProt :accession O00257