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CBLB502
polypeptide derived from Salmonella flagellin
Indications:
- radioprotective agent during radiation therapy
A single injection of CBLB502 prior to lethal total body radiation protects mice from gastrointestinal & hematopoietic acute radiation syndrome & results in improved survival does not decrease tumor radiosensitivity CBLB502 is protective in lethally irradiated rhesus monkeys [1]
Mechanism of action:
- toll-like receptor-5 TLR5 agonist, activates NF-kappa D signalling
General
bacterial protein
References
- Burdelya LG et al,
An agonist of toll-like receptor 5 has radioprotective
activity in mouse and primate models.
Science 2008, 320:226
PMID: 18403709