core-binding factor [CBF]-beta selections

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core-binding factor [CBF]-beta; polyomavirus enhancer binding protein 2 beta; PEBP2-beta; SL3/AKV core-binding factor beta; SL3-3 enhancer factor 1 beta (CBFB)

Function: - beta subunit of core-binding factor - CBFB enhances DNA binding by RUNX1 - heterodimer with RUNX1 Structure: belongs to the CBF-beta family Compartment: nucleus (putative) Pathology: - chromosomal inversion inv(16)(p13;q22) involving CBFB with MYH11 is associated with AML-M4

AML-M4; acute myelomonocytic leukemia

General

transcription factor (TF)

Properties

SIZE: entity length = 182 aa MW = 22 kD COMPARTMENT: cell nucleus MOTIF: Breakpoint {165-166}

Database Correlations

OMIM 121360 UniProt Q13951 Entrez Gene 865

References

Liu et al, Fusion between transcription factor CBF beta/PEB2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041 1993 PMID: 8351518
Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/CBFbID45.html
UniProt :accession Q13951

Component-of

core-binding factor (CBF) or polyoma virus enhancer-binding protein-2 (PEBP2)

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