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Ca+2 uptake protein 1, mitochondrial; atopy-related autoantigen CALC; ara CALC; Ca+2-binding atopy-related autoantigen 1; allergen hom s 4 (MICU1 CALC CBARA1)
Function:
- induces T helper 1-mediated autoreactivity, which is accompanied by the release of IFNG
- regulator of mitochondrial Ca+2 uptake required for Ca+2 entry into mitochondria
- may act as a Ca+2 sensor via its EF-hand domains, gating activity of a Ca+2 channel partner.
- interacts with MCU
Structure:
- the EF-hand domains are required for mitochondrial Ca+2 homeostasis function
- contains 2 EF-hand domains
Compartment: mitochondrial inner membrane (putative)
Alternative splicing: named isoforms=5
Expression:
- expressed in epithelial cell line
- strongly expressed in epidermal keratinocytes & dermal endothelial cells
Pathology:
- causes an allergic reaction in human
- binds to IgE from atopic dermatitis patients
- identified as an IgE autoantigen in atopic dermatitis patients with severe skin manifestations
General
Ca+2 binding protein
mitochondrial membrane protein
Properties
SIZE: entity length = 476 aa
MW = 54 kD
COMPARTMENT: mitochondria
MOTIF: transmembrane domain {33-52}
EF hand
SITE: 218-253
MOTIF: Ca+2-binding site
SITE: 231-242
EF hand
SITE: 408-443
MOTIF: Ca+2-binding site
SITE: 421-432
Database Correlations
OMIM 605084
UniProt Q9BPX6
Entrez Gene 10367
Kegg hsa:10367
References
UniProt :accession Q9BPX6