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caveolin-1 (CAV1, CAV)
Function:
- may act as a scaffolding protein within caveolar membranes
- interacts directly with G-protein alpha subunits & can functionally regulate their activity (putative)
- role in costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation
- binding to DPP4 induces T-cell proliferation & NF-kappa-B activation (T-cell receptor/CD3-dependent)
- interacts with GLIPR2, NOSTRIN, SNAP25 & syntaxin
- interacts with rotavirus A NSP4
- interacts (via the N-terminus) with DPP4
Structure:
- initiator Met for isoform beta is removed during or just after translation; the new N-terminal amino acid is then N-acetylated
- homooligomer
- belongs to the caveolin family
Compartment:
- Golgi membrane
- cell membrane
- caveola
- membrane raft
- colocalized with DPP4 in membrane rafts
- potential hairpin- like structure in the membrane
- membrane protein of caveolae
Alternative initiation:
- named isoforms=2; alpha, beta
- initiator Met-1 is removed
- contains a N-acetylalanine at position 2
Expression:
- expressed in muscle & lung
- lower expression in liver, brain & kidney
Pathology:
- defects in CAV1 are the cause of congenital generalized lipodystrophy type 3
Notes:
- 1st structural component of caveolae identified
- when integrated into the microenvironment of a lipid raft, a caveola develops.
General
caveolin
phosphoprotein
Properties
SIZE: entity length = 178 aa
MW = 20 kD
COMPARTMENT: golgi
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y6}
Tyr phosphorylation site {Y14}
Tyr phosphorylation site {Y25}
Ser phosphorylation site {S37}
Tyr phosphorylation site {Y42}
transmembrane domain {105-125}
cysteine residue {C133}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C143}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C156}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM correlations
MORBIDMAP 601047
UniProt Q03135
Pfam PF01146
Entrez Gene 857
Kegg hsa:857
References
- UniProt :accession Q03135
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/CAV1ID932ch7q31.html
- Wikipedia; Note: Caveolin entry
http://en.wikipedia.org/wiki/Caveolin
- OMIM :accession 601047
- Galbiati F et al,
Emerging themes in lipid rafts and caveolae.
Cell 106:403, 2001
PMID: 11525727