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catecholamine
Includes:
- dopamine
- epinephrine
- norepinephrine
Hormones released by the adrenal medulla in response to stress.
Norepinephrine is also produced by post ganglionic fibers of the sympathetic nervous system & by melanin-pigmented cells in the locus ceruleus.
Dopamine is also produced by neurons in the ventral tegmental area & the substantia nigra.
Function:
- hormones in circulating blood
- norepinephrine & dopamine also act as neurotransmitters
- intracellular effects mediated by G-protein linked receptors
- adrenergic receptors
- dopamine receptors
Pharmacokinetics:
- protein binding ~ 50%
- 1/2 life of a few minutes
- metabolized by
- catecholamine-0-methyltransferase (methylation)
- monoamine oxidase (deamination)
Related
catecholamine metabolism
catecholamines in body fluid
Specific
3-methoxydopamine
arbutamine
benserazide (Serazide)
carbidopa (Lodosyn)
dopamine (Inotropin, Dopastat)
droxidopa (Northera, L-DOPS)
epinephrine; adrenaline (Sus-Phrine, Vapronefrin, Epifrin, Glaucon, Auvi-Q, Allerject)
isoproterenol
levodopa; L-3-hydroxytyrosine; L-3,4-dihydroxyphenylalanine; L-dopa (Dopar, Larodopa, Inbrija)
levonordefrin; alpha-methylnorepinephrine (Corbadrine, Neo-Cobefrin)
metanephrine
norepinephrine; noradrenaline (Levophed)
normetanephrine
General
amine
catechol
References
- Wikipedia: catecholamine
http://en.wikipedia.org/wiki/Catecholamine