caspase-7; ICE-like apoptotic protease 3; ICE-LAP3; Mch-3 protein (CASP7, MCH3)

Function: - role in the activation cascade of caspases responsible for apoptosis execution - cleaves sterol regulatory element binding proteins (SREBPs) & activates them - proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-gly-217' bond - cleavages by granzyme B or caspase-10 generate the two active subunits - propeptide domains can also be cleaved efficiently by caspase-3 - strict requirement for an Asp residue at position P1 & has a preferred cleavage sequence of Asp-Glu-Val-Asp-|- Inhibition: inhibited by isatin sulfonamides Structure: - active heterodimers between the small subunit of caspase-7 & the large subunit of caspase-3, & vice versa, also occur - overexpression promotes programmed cell death heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kD (p20) & a 11 kD (p11) subunit - belongs to the peptidase C14 family Compartment: cytoplasm Alternative splicing: named isoforms=3 Expression: - expressed in lung, skeletal muscle, liver, kidney, spleen & heart > testis - no expression in brain

Properties

SIZE: entity length = 303 aa MW = 34 kD COMPARTMENT: cytoplasm MOTIF: histidine residue {H144} cysteine residue {C186}

Database Correlations

OMIM 601761 UniProt P55210 Pfam PF00656 Entrez Gene 840 KEGG correlations ENZYME 3.4.22.60

References

UniProt :accession P55210