caspase-1 inhibitor COP; CARD only domain-containing protein 1; pseudo interleukin-1 beta converting enzyme; pseudo-ICE (COP1, COP, CARD16)

Function: - caspase inhibitor - acts as a regulator of procaspase-1/CASP1 activation implicated in regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) & its release during inflammation - inhibits the release of IL1B in response to LPS in monocytes - also induces NF-kappa-B activation during the pro-inflammatory cytokine response - also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, & staurosporine-mediated cell death but not ER stress-mediated cell death. - acts by preventing activation of caspases CASP1 & CASP4, possibly by preventing the interaction between CASP1 & RIPK2 Structure: - homooligomer - interacts with CASP1, CASP4, CARD8 & RIPK2 - contains 1 CARD domain Alternative splicing: named isoforms=2 Expression: - widely expressed - expressed at higher level in placenta, spleen, lymph node & bone marrow - weakly or not expressed in thymus Pathology: - down-regulated in patients with Huntington disease

General

protease inhibitor other protein

Properties

SIZE: entity length = 197 aa MW = 23 kD MOTIF: CARD domain {1-91} INHIBITS: protease

Database Correlations

UniProt Q5EG05 Pfam PF00619 Kegg hsa:1147

References

UniProt :accession Q5EG05