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caspase-12; CASP-12 (CASP12)
Function:
- has no protease activity
- may reduce cytokine release in response to bacterial lipopolysaccharide during infections
- reduces activation of NF-kappa-B in response to TNF
Structure:
- belongs to the peptidase C14 family
- contains 1 CARD domain
Alternative splicing: named isoforms=3
Expression:
- detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus & testis
Pathology:
- may also contribute to A4 peptide neurotoxicity
Polymorphism:
- most frequent variant has a stop codon instead of Arg-125, giving rise to a truncated protein (Csp12-S)
- the variant Arg-125 (Csp12-L) is rare, except in some populations from sub-Saharan Africa
- Csp12-L may increase the susceptibility to severe sepsis, & may also increase the mortality rate in sepsis patients
General
caspase; cysteinyl aspartate-specific proteinase; ICE/CED3 family protease
Properties
SIZE: entity length = 341 aa
MW = 39 kD
MOTIF: CARD domain {1-92}
histidine residue {H172}
cysteine residue {C220}
Database Correlations
OMIM 608633
UniProt Q6UXS9
PFAM correlations
Kegg hsa/hsa04210
References
- UniProt :accession Q6UXS9
- Nakagawa et al. Nature 403:98-103, 2000