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caskin-1 (CASK-interacting protein 1, CASKIN1, KIAA1306)
Function:
- may link the scaffolding protein CASK to downstream intracellular effectors
- binds CaM kinase domain of CASK
- forms a ternary complex with CASK & LIN7A, LIN7B or LIN7C
- competes with APBA1 that forms a similar complex with CASK & LIN7 proteins
- tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds cytoplasmic tail of NRXN1
Structure:
- contains 6 ANK repeats
- contains 2 SAM domains (sterile alpha motif)
- contains 1 SH3 domain
Compartment: cytoplasm
General
phosphoprotein
Properties
SIZE: MW = 150 kD
entity length = 1431 aa
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 48-77
ankyrin repeat
NAME: ankyrin repeat
SITE: 81-110
ankyrin repeat
NAME: ankyrin repeat
SITE: 114-143
ankyrin repeat
NAME: ankyrin repeat
SITE: 147-176
ankyrin repeat
NAME: ankyrin repeat
SITE: 188-217
ankyrin repeat
NAME: ankyrin repeat
SITE: 220-249
src homology 3 [SH3] domain
SITE: 281-347
binding site
SITE: 375-469
FOR-BINDING-OF: peripheral plasma membrane protein CASK
sterile alpha motif
NAME: sterile alpha motif
SITE: 472-535
sterile alpha motif
NAME: sterile alpha motif
SITE: 541-605
Ser phosphorylation site {S646}
proline-rich region
SITE: 714-1365
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T775}
Ser phosphorylation site {S787}
Thr phosphorylation site {T1065}
Ser phosphorylation site {S1067}
Ser phosphorylation site {S1257}
Ser phosphorylation site {S1364}
Database Correlations
UniProt Q8WXD9
PFAM correlations
References
UniProt :accession Q8WXD9