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alpha-S1-casein; contains: casoxin-D (CSN1S1, CASA, CSN1)
Function:
- important role in the capacity of milk to transport Ca+2 phosphate
- not glycosylated
- heteromultimers of alpha-s1 casein & kappa-casein
Structure:
- disulfide-linked
- belongs to the alpha-casein family
Compartment: secreted
Alternative splicing: named isoforms=3
Expression:
- mammary gland specific
- secreted in milk
Note:
- in milk, the alpha s1- & beta-caseins precipitate in presence of Ca+2 (so-called Ca+2-sensitive caseins)
- kappa-casein prevents the precipitation of the other caseins by Ca+2 through formation of large stable colloidal particles termed micelles
Specific
casoxin D
General
casein
Properties
SIZE: entity length = 185 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
Ser phosphorylation site {S31}
Ser phosphorylation site {S33}
Ser phosphorylation site {S41}
Ser phosphorylation site {S86}
Ser phosphorylation site {S88}
Ser phosphorylation site {S89}
Ser phosphorylation site {S90}
Ser phosphorylation site {S91}
Database Correlations
OMIM 115450
UniProt P47710
Entrez Gene 1446
Kegg hsa:1446
References
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- White et al Principles of Biochemistry,
McGraw Hill Inc., New York, NY 1978 pg 1061
- UniProt :accession P47710
- Protein Spotlight; Of buttons, digestion & glue
Issue 16 of November 2001
http://www.expasy.org/spotlight/back_issues/sptlt016.shtml