Carney complex

Pathology: 1) myxomas, cardiac & skin 2) pituitary adenoma a) Cushing's syndrome (ACTH) b) acromegaly (GH-secreting) {20%} 3) testicular Sertoli cell tumors 4) pigmented micronodular adrenal hyperplasia 5) spotty cutaneous pigmentation 6) myxoid fibroadenomas, breast 7) psammomatous melanotic schwannomas Genetics: 1) type 1 associated with defects in PRKAR1A gene 2) chromosomal aberration (microsatellite instability) 2p16 (type 2) 3) variant form associated with defects in MYH8 4) telomere alteration ?

Specific

Carney complex 1 Carney complex 2

Properties

ASSOCIATED-NEOPLASM[S]: myxoma pituitary adenoma schwannoma fibroadenoma pheochromocytoma