Search
troponin T, cardiac muscle; TnTc; cardiac muscle troponin T; cTnT (TNNT2)
Function:
- tropomyosin binding subunit of troponin, the thin filament regulatory complex which confers Ca+2 sensitivity to striated muscle actomyosin ATPase activity
- essential in sarcomere assembly & cardiac contractility (zebrafish)
Structure: belongs to the troponin T family
Alternative splicing: named isoforms=10; additional isoforms seem to exist. experimental
Expression:
- expressed in heart
- fetal heart shows a greater expression in the atrium than in the ventricle
- adult heart shows a greater expression in the ventricle than in the atrium
- isoform 6 predominates in normal adult heart
- isoforms 1, 7 & 8 are expressed in fetal heart
- isoform 7 is also expressed in failing adult heart
Pathology:
1) defects in TNNT2 are the cause of
a) familial hypertrophic cardiomyopathy type 2
b) dilated cardiomyopathy type 1D
c) familial restrictive cardiomyopathy type 3
2) even very low plasma levels of cardiac troponin T are associated with increased risk for heart failure & cardiovascular death among patients with stable heart disease [5]
Related
troponin
troponin T cardiac in serum/plasma
General
troponin-T
Properties
SIZE: entity length = 298 aa
MW = 36 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S2}
Database Correlations
OMIM correlations
MORBIDMAP 191045
UniProt P45379
Pfam PF00992
Entrez Gene 7139
References
- UniProt :accession P45379
- Sehnert AJ et al
Cardiac troponin T is essential in sarcomere assembly and
cardiac contractility.
Nature Genetics 31:106-110, 2002
PMID: 11967535
- Familial hypertrophic cardiomyopathy mutation database
http://www.angis.org.au/Databases/heart/heartbreak.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TNNT2
- Omland T et al for the the Prevention of Events with
Angiotensin Converting Enzyme Inhibition (PEACE) Trial
Investigators.
A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery
Disease
N Engl J Med. 2009 Nov 25. [Epub ahead of print]
PMID: 19940289
http://content.nejm.org/cgi/content/full/NEJMoa0805299