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cardiac Stem Cell Therapy
Indications:
- treatment of congestive heart failure due to chronic ischemic heart disease & myocardial infarction
- moderate quality evidence of improved LVEF [2]
Clinical trials:
- BOOST study
- many others [2]
Notes:
- benefits cited in most trials probably overestimated [1]
Related
BOOST study (stem cell infusion for MI)
General
stem cell transplantation
References
- Nowbar AN et al
Discrepancies in autologous bone marrow stem cell trials and
enhancement of ejection fraction (DAMASCENE): weighted
regression and meta-analysis.
BMJ 2014;348:g2688
PMID: 24778175
http://www.bmj.com/content/348/bmj.g2688
- Fisher SA et al
Stem cell therapy for chronic ischaemic heart disease and
congestive heart failure.
Cochrane Database Syst Rev. 2014 Apr 29;4:CD007888
PMID: 24777540
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007888.pub2/abstract