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sucralfate (Carafate)
Tradename: Carafate.
Indications:
1) treatment of duodenal ulcers
2) used to accelerate healing of gastric ulcers
3) treatment of gastroesophageal reflux & peptic esophagitis
- pyrosis
- no role in treatment of GERD [4]
4) stress ulceration
- 1st line therapy for stress ulcer prophylaxis
5) topical treatment for stomatitis due to cancer chemotherapy
Contraindications:
pregnancy-category B
safety in lactation ?
Dosage:
1) 1 g PO 1 hour before meals & QHS [1]
2) 1 gm QID or 2 g BID [2]
3) give sucralfate 1 hour before or 3-4 hours after other medicines
Tabs: 1 g.
Suspension: 1g /10 mL (420 mL).
Pharmacokinetics:
1) minimally absorbed from GI tract
2) excreted in feces
Adverse effects:
1) not common (1-10%)
- constipation
2) uncommon (< 1%)
- dizziness, sleepiness, vertigo, rash, pruritus, diarrhea, nausea, gastric discomfort, indigestion, dry mouth, back pain
Drug interactions:
1) sucralfate may diminish effect of warfarin
2) sucralfate may diminish bioavailability of:
a) digoxin
b) quinolines
c) phenytoin
d) ketoconazole
3) cimetidine
Mechanism of action:
1) forms an adherent complex that protects ulcer site from acidic environment
2) inhibits pepsin activity
3) contains aluminum
General
antiulcer agent
Database Correlations
PUBCHEM cid=5311464
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Geriatric Review Syllabus, 8th edition (GRS8)
Durso SC and Sullivan GN (eds)
American Geriatrics Society, 2013
Component-of
Benadryl/Carafate/Mylanta
magic mouthwash