Captopril Prevention Project (CAPPP)

The study tested the effect of the ACE inhibitor captopril in 11,000 patients in Sweden & Finland. Patients received either captopril & a diuretic if necessary or diuretics, beta-blocker or both. During an average follow-up of 6 years, there were no difference in the group in the frequency of myocardial infarction or stroke. In a subset of 572 diabetic patients with diastolic blood pressure > 100 mm Hg Combined endpoint: - fatal stroke - myocardial infarction - sudden death Results: 1) combined endpoint less freatuent in captopril group adjusted relative risk 0.59 2) no difference in risk of stroke 3) myocardial infarction less frequent in captopril group adjusted relative risk 0.34

Related

captopril (Capoten) diabetes mellitus

References

- Journal Watch 22(2):13, 2002 Niskanen L et al Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-lin therapy with and ACE inhibitor compared with a diuretic/beta-blocker-based treatment regimen: a subanalysis of the Captopril Prevention Project. Diabetes Care 24:2091, 2001 PMID: 11723089