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calpain-10 catalytic subunit (digestive tract-specific calpain, nCL-4, CG36 protein, CAPN9, NCL4)
Function:
- Ca+2-regulated non-lysosomal thiol-protease
- broad endopeptidase specificity
Structure:
- belongs to the peptidase C2 family
- contains 1 calpain catalytic domain
- contains 3 EF-hand domains
Alternative splicing: named isoforms=2
Expression: expressed predominantly in stomach
Pathology:
- down-regulated in gastric cancer tissue & in gastric cell lines of differentiated & poorly differentiated types
General
calpain catalytic or large subunit
Properties
SIZE: entity length = 690 aa
MW = 79 kD
MOTIF: catalytic domain
SITE: 42-337
MOTIF: cysteine residue {C97}
histidine residue {H254}
asparagine residue {N278}
Domain III {338-521}
EF hand
SITE: 518-552
Domain IV {522-690}
MOTIF: EF hand
SITE: 561-594
Ca+2-binding site
SITE: 574-585
EF hand
SITE: 591-626
Ca+2-binding site
SITE: 604-615
Database Correlations
OMIM 606401
UniProt O14815
PFAM correlations
Kegg hsa:1075
References
UniProt :accession O14815
Component-of
calpain-9