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calpain-10 catalytic subunit (Ca+2-activated neutral proteinase 10, CANP 10, CAPN10, KIAA1845)
Function:
- Ca+2-regulated non-lysosomal thiol-protease
- catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling & signal transduction
- broad endopeptidase specificity
Structure:
- belongs to the peptidase C2 family
- contains 1 calpain catalytic domain
Alternative splicing: named isoforms=8
Expression: ubiquitous
Pathology:
- genetic variations in CAPN10 are associated with susceptibility diabetes mellitus type 2
General
calpain catalytic or large subunit
Properties
SIZE: entity length = 672 aa
MW = 75 kD
MOTIF: catalytic domain
SITE: 13-321
MOTIF: cysteine residue {C73}
histidine residue {H238}
asparagine residue {N263}
Domain III 1 {322-494}
Domain III 2 {513-654}
Database Correlations
OMIM correlations
MORBIDMAP 605286
UniProt Q9HC96
PFAM correlations
References
UniProt :accession Q9HC96
Component-of
calpain-10