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Combined Angiolasty & Pharmacologic Intervention versus Thromboylisis ALone in Acute Mycocardial Infarction (CAPITAL AMI) study

Design: - 170 patients with STEMI Treatmemt: - tenecteplase-facilitated angioplasty vs tenecteplase alone Primary endpoint: - composite death, reinfarction, recurrent unstable angina or stroke at 6 months Results: primary endpoints reached in:* 12% of tenecteplase-facilitated angioplasty group 21% of tenecteplase alone group * difference significant due to reduction in recurrent unstable angina (8% vs 21%) & trend towards reduction in reinfarction (5% vs 15%) no difference in rates of stroke or death No differences is major bleeding (8% vs 7%)

Related

percutaneous transluminal coronary angioplasty (PTCA)

General

clinical trial

References

  1. Le May MR, Wells GA, Labinaz M, Davies RF, Turek M, Leddy D, Maloney J, McKibbin T, Quinn B, Beanlands RS, Glover C, Marquis JF, O'Brien ER, Williams WL, Higginson LA. Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). J Am Coll Cardiol. 2005 Aug 2;46(3):417-24. PMID: 16053952