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cancer of unknown primary

Radiology: - CT of chest, abdomen & pelvis Management: special cases: - carcinoma identified in isolated enlarged inguinal lymph node - if CT negative - examination of the vulva, vagina, cervix, anus (women)* - penis, anus (men)* - axillary presentation of adenocarcinoma - axillary dissection & treat as primary breast cancer [1] * anoscopy vs colonoscopy & upper GI

Specific

metastatic cancer of unknown primary

General

carcinoma

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018 - Medical Knowledge Self Assessment Program (MKSAP) 20 American College of Physicians, Philadelphia 2025
  2. Laprovitera N, Riefolo M, Ambrosini E, et al. Cancer of unknown primary: challenges and progress in clinical management. Cancers (Basel). Published online January 25, 2021. 2021;13(3):451. PMID: 33504059
  3. NCCN Clinical Guidelines in Oncology. Occult Primary. Version 2.2024. https://www.nccn.org/professionals/physician_gls/pdf/occult.pdf