cancer antigen CA 19-5 in serum

Clinical significance: The CA 19-5 antigen: 1) the epitope is recognized by mouse monoclonal antibody CC3C-195 2) CC3C-195 reacts with Lewis blood substance Le(a) & with higher affinity with sialyl Le(a) 8) CA 19-9 & CA 50 are related to CA-19-5 CA 19-9, CA 19-5 & CA 50 in serum are elevated in: 1) gastric carcinoma 2) pancreatic carcinoma 3) hepatocellular carcinoma CA 19-9, CA 19-5 & CA 50 may be also elevated by cholestasis. Increases: 1) gastric carcinoma 2) pancreatic carcinoma 3) hepatocellular carcinoma 4) cholestasis

References

Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1075-76