calcium/calmodulin-dependent protein kinase II delta (CAMK2D)

Function: - one of 4 CaM-kinase 2 subunits that comprise CaM-kinase 2 complex Structure: - belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. CaMK subfamily - contains 1 protein kinase domain Alternative splicing: named isoforms=9 Expression: - expressed in cardiac muscle & skeletal muscle - isoform delta 3, isoform delta 2, isoform delta 8 & isoform delta 9 are expressed in cardiac muscle - isoform delta 11 is expressed in skeletal muscle Pathology: - expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy

General

calmodulin binding protein phosphoprotein protein subunit serine/threonine kinase

Properties

SIZE: entity length = 499 aa MW = 56 kD STATE: active state MOTIF: kinase domain SITE: 14-272 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 20-28 ATP-binding site NAME: ATP-binding site SITE: 43-43 aspartate residue {D136} Tyr phosphorylation site {Y231} Thr phosphorylation site {T287} binding site SITE: 291-301 FOR-BINDING-OF: calmodulin Ser phosphorylation site {S315} Ser phosphorylation site {S319} Thr phosphorylation site {T337}

Database Correlations

OMIM 607708 UniProt Q13557 PFAM correlations Entrez Gene 817 Kegg hsa:817 ENZYME 2.7.11.17

References

UniProt :accession Q13557