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calcium/calmodulin-dependent protein kinase II beta (CAMK2B, CAMKB)
Function:
- one of 4 CaM-kinase 2 subunits that comprise CaM-kinase 2 complex
- interacts with SYNGAP1 (putative)
- interacts with MPDZ
- autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. CaMK subfamily
- contains 1 protein kinase domain
Alternative splicing:
- named isoforms=7
- variable region of the CAMK2B protein is encoded by
- at least 7 exons (V1 to V7)
- alternative splicing within this region gives rise to CAMK2B isoforms
Expression:
- widely expressed
- expressed in adult & fetal brain
- expression slightly lower in fetal brain
General
calmodulin binding protein
phosphoprotein
protein subunit
serine/threonine kinase
Properties
SIZE: entity length = 664 aa
MW = 73 kD
STATE: active state
MOTIF: kinase domain
SITE: 14-272
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 20-28
Tyr phosphorylation site {Y17}
ATP-binding site
NAME: ATP-binding site
SITE: 43-43
aspartate residue {D136}
Thr phosphorylation site {T287}
binding site
SITE: 291-301
FOR-BINDING-OF: calmodulin
Ser phosphorylation site {S315}
Ser phosphorylation site {S367}
Ser phosphorylation site {S397}
Database Correlations
OMIM 607707
UniProt Q13554
PFAM correlations
Entrez Gene 816
Kegg hsa:816
ENZYME 2.7.11.17
References
- Nestler & Greengard Basic Neurochemistry ch 19 1989
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- UniProt :accession Q13554
Component-of
calcium/calmodulin dependent protein kinase 2