Search
calcium/calmodulin-dependent protein kinase II alpha (CAMK2A, CAMKA, KIAA0968)
Function:
- one of 4 CaM-kinase 2 subunits that comprise CaM-kinase 2 complex
- interacts with BAALC, MPDZ, SYN1 & SYNGAP1 (putative)
- autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state (putative)
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
- contains 1 protein kinase domain
Compartment:
- cell junction, synapse
- presynaptic cell membrane (putative)
- postsynaptic lipid rafts (putative)
Alternative splicing: named isoforms=2
Related
CaM kinase 2-alpha gene
General
calmodulin binding protein
phosphoprotein
protein subunit
serine/threonine kinase
Properties
SIZE: entity length = 478 aa
MW = 54 kD
STATE: active state
MOTIF: kinase domain
SITE: 13-271
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 19-27
Tyr phosphorylation site {Y13}
Ser phosphorylation site {S25}
ATP-binding site
NAME: ATP-binding site
SITE: 42-42
aspartate residue {D135}
Ser phosphorylation site {S275}
Thr phosphorylation site {T286}
binding site
SITE: 290-300
FOR-BINDING-OF: calmodulin
BAALC interaction {310-320}
Ser phosphorylation site {S333}
Thr phosphorylation site {T334}
Thr phosphorylation site {T337}
Database Correlations
OMIM 114078
UniProt Q9UQM7
PFAM correlations
Entrez Gene 815
ENZYME 2.7.11.17
References
- Nestler & Greengard Basic Neurochemistry ch 19 1989
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- UniProt :accession Q9UQM7
Component-of
calcium/calmodulin dependent protein kinase 2