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calprotectin in stool (S100A8/A9 in stool)
also see serum S100A8/A9 (calprotectin in serum)
Indication:
- diagnosis of inflammatory bowel disease (IBD)
- index of suspicion not high
- cost-effective when the pretest probability of IBD is <= 75% (adults) & <= 65% (children) [1]
- monitoring of ulcerative colitis (or other colitis) [3]
- rising levels warrant endoscopic evaluation
- can be used to monitor for postoperative recurrences
Reference interval:
- 50 ug/g
Clinical significance:
- calprotectin is shed in the stool of patients with inflammatory bowel disease
Related
calprotectin complex (S100A8/A9)
protein S100-A8; S100 Ca+2-binding protein A8; calgranulin-A; migration inhibitory factor-related protein 8; MRP-8; p8; Cystic fibrosis antigen; CFAG; Leukocyte L1 complex light chain; calprotectin L1L subunit; urinary stone protein band A (S100A8, CAGA, CFAG, MRP8)
protein S100-A9; S100 Ca+2-binding protein A9; calgranulin-B; migration inhibitory factor-related protein 14; MRP-14; p14; Leukocyte L1 complex heavy chain; calprotectin L1H subunit (S100A9, CAGB, CFAG, MRP14)
General
special chemistry test
References
- Calprotectin, Fecal
Laboratory Test Directory ARUP: 92303
- Calprotectin, Fecal
https://arupconsult.com/ati/calprotectin-fecal
- Yang Z et al.
Effectiveness and cost-effectiveness of measuring fecal
calprotectin in diagnosis of inflammatory bowel disease in
adults and children.
Clin Gastroenterol Hepatol 2014 Feb; 12:253
PMID: 23883663
- Colombel JF, Narula N, Peyrin-Biroulet L.
Management Strategies to Improve Outcomes of Patients with
Inflammatory Bowel Diseases.
Gastroenterology. 2016 Oct 5.
PMID: 27720840