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calpain
Calpains are a superfamily of related proteins
Function:
- some have been shown to function as intracellular Ca+2- dependent cysteine proteases
- role in cytosolic/nuclear proteolytic signalling
Structure:
- variable large (80 kD) catalytic subunit & an invariant small regulatory (30 kD) subunit
Interactions
molecular events
Specific
calpain-1 or calcium-activated neutral protease-mu type
calpain-2 or calcium-activated neutral protease-M type
calpain-3
calpain-5
calpain-6
calpain-7
calpain-8; stomach-specific M-type calpain; new calpain 2; nCL-2 (CAPN8, NCL2)
calpain-9
calpain-10
calpain-11
calpain-12 (CAPN12)
calpain-13 (CAPN13)
calpain-14 (CAPN14)
calpain-15; small optic lobes homolog (SOLH, CAPN15)
General
cysteine proteinase; thiol proteinase
multisubunit protein
PEST protein
Properties
COMPARTMENT: cytoplasm
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBUNITS: calpain catalytic subunit
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
active site
MOTIF: cysteine residue
calpain regulatory subunit
QUALITIES: PROTEIN-FRAGMENT
:PART C-TERMINAL
MOTIF: Ca+2-binding site
References
- OMIM :accession 604822
- Leist M, Jaattela M.
Four deaths and a funeral: from caspases to alternative
mechanisms.
Nat Rev Mol Cell Biol. 2001 Aug;2(8):589-98. Review.
PMID: 11483992
Component-of
molecular complex
Components
calpain catalytic or large subunit
calpain regulatory [small] subunit (CANP small subunit)