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protein S100-A6; S100 Ca+2-binding protein A6; calcyclin; prolactin receptor-associated protein; PRA; growth factor-inducible protein 2A9; MLN 4 (S100A6, CACY)

Function: - interacts with SUGT1 Structure: - homodimer, antiparallel - the N-terminus is blocked - belongs to the S-100 family - contains 2 EF-hand domains Expression: - preferentially expressed when quiescent fibroblasts are stimulated to proliferate - inducible by growth factors Pathology: - overexpressed in acute myeloid leukemias Notes: co-purified with prolactin receptor

Related

S100 Ca+2-binding protein

General

Ca+2 binding protein

Properties

SIZE: entity length = 90 aa MW = 10 kD MOTIF: EF hand SITE: 12-47 MOTIF: Ca+2-binding site SITE: 20-33 EF hand SITE: 48-83 MOTIF: Ca+2-binding site SITE: 61-72

Database Correlations

OMIM 114110 UniProt P06703 PFAM correlations Entrez Gene 6277 Kegg hsa:6277

References

  1. UniProt :accession P06703
  2. OMIM :accession 114110