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calcitonin gene-related peptide (CGRP) inhibitor
Indications:
- prevention of migraine [1]
Dosage:
- monthly injections [1]
Adverse effects:
- appear to be minimal [1]
Mechanism of action:
- inhibition of CGRP receptor
- includes monoclonal antibody to CGRP & small molecules gepants able to cross the blood brain barrier
Related
calcitonin gene-related peptide (CGRP)
Specific
eptinezumab
erenumab (Aimovig)
galcanezumab (Emgality)
gepant
telcagepant (MK-0974)
zavegepant (Zavzpret)
General
anti-migraine agent
References
- NEJM JWatch editors
Early Results for Experimental Migraine Prevention Meds Look
Promising.
Physician's First Watch, June 18, 2015
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- American Headache Society. Public Release: June 17, 2015
Studies at American Headache Society Meeting show promise
in new migraine prevention drugs. CGRP antagonists first
mechanism-specific treatments developed to prevent migraine
http://www.eurekalert.org/pub_releases/2015-06/tc-saa061515.php