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calcineurin; serine/threonine protein phosphatase 3 (formerly PP2B)
Function:
- Ca+2-dependent, calmodulin-stimulated Ser/Thr phosphatase
- dephosphorylates HSPB1 & SSH1
- more restricted in its specificity than protein phosphatase 1 & protein phosphatase 2A
- releases cytosolic NFAT components for nuclear transloaction
Structure:
- composed of two components (A & B)
- the A component is the catalytic subunit
- the B component confers Ca+2 sensitivity
Pharmacology:
- calcineurin inhibitors used as immunosuppressive agents in prevention of organ transplant rejection
Laboratory:
- protein phosphatase 3 in leukocytes
Interactions
molecular events
Related
calcineurin inhibitor
nuclear factor of activated T-cells (NFATC transcription complex, NFAT)
General
calmodulin binding protein
multisubunit protein
serine/threonine phosphatase
Properties
STATE:
active state
MOTIF:
active site
SUBUNITS:
calcineurin-A
MOTIF: catalytic domain
MOTIF: Iron [Fe]-binding site
Zn+2-binding site
histidine residue
calmodulin binding site
FOR-BINDING-OF: calmodulin
calcineurin-B
MOTIF: myristoylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: myristate
Ca+2-binding site
MISC-INFO: Kd [calmodulin] 6 NM
Kd [Ca+2] 1 UM
LIGAND = FK506
LIGAND = CYCLOSPORIN
References
- OMIM :accession 114105
- Ingebritsen TS, Cohen P.
Protein phosphatases: properties and role in cellular
regulation.
Science. 1983 Jul 22;221(4608):331-8.
PMID: 6306765
- Armstrong DL
Calcium channel regulation by calcineurin, a Ca+2-activated
phosphatase in mammalian brain
TINS 12(3):117 1989
PMID: 2469218
- Wikipedia, calcineurin entry
http://en.wikipedia.org/wiki/calcineurin
Component-of
molecular complex
Components
calcineurin-A or phosphatase-3 (2B) catalytic subunit
calcineurin-B or phosphatase-3 (2B) regulatory subunit